It was an emotional victory for Pacquiao after a devastating typhoon swept through his home nation of the Philippines this month, killing thousands.
"This is not about my comeback," Pacquiao said in the ring. "My victory is a symbol of my people's comeback from a natural disaster and a natural tragedy."
Back in the ring for the first time in almost a year, Pacquiao wore Rios down with his trademark combination punching and won 120-108, 119-109 and 118-110 on the scorecards at The Venetian casino in Macau.
Manny Pacquiao defeated Brandon Rios by unanimous decision on Sunday, returning to his winning ways after consecutive losses.